↑ Alexander Saytzeff (1874): Ueber die Reduction des Succinylchlorids. Liebigs Annalen der Chemie. 171: 258-290.
↑ An author/scientist Gian Luigi Gessa has been researching alcoholism and the effects of various drugs to persons afflicted with said disease for the past ten years. His studies in 1998 note that GHB, tuz
tudzież pharmaceutical aid, can be much less toxic and much more effective than the leading pharmaceutical compound (disulfiram)
↑ In clinical trials Xyrem significantly reduced cataplexy attacks at tudzież dose of 6000–9000mg per night. This is around three times the dose used recreationally, obuwie
almost all narcolepsy patients in the clinical trials were already stabilized pan CNS stimulants such tuz
modafinil; in patients not prescribed modafinil, this dosage could be dangerous and should be reduced appropriately. Also the prescribing information for Xyrem states that patients should take the dose immediately before going to bed, and then oraz second dose 3–4 hours later. The maximum dose taken at one time should not exceed 4500 mg. Patients with hepatic insufficiency (compromised liver function) have slower clearance of GHB and require reduced doses, typically half the normal dose. Xyrem oral solution is standardised to 500 mg Na.GHB / 1 mL water, buffered to pH 7.5 with malic acid.